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| Catalog: | C-EL-2006T |
| Product Type: | Test kit |
| Size: | 96 tests |
| Principle: | Sandwich ELISA |
| Species: | Human |
| Detection range: | 62.5-4000 pg/mL |
| Sensitivity: | 3.0 pg/mL |
| Sample type: | Serum, Plasma, Cell culture supernatants, Urine, Saliva |
| Test type: | Quantitative |
| Analysis mode: | ELISA |
| Storage: | All the reagents are stored at 2-8℃. Refer to the protocol for further storage instructions. |
| Synonyms:: | BP, HAPT, haptoglobin, HP, HP2 ALPHA 2, HPA1S |
| Application: | Granzyme B (GZMB) is also named as CGL1, CSPB, CTLA1, GRB and belongs to the Granzyme subfamily. This enzyme is necessary for target cell lysis in cell-mediated immune responses. The cytotoxic lymphocyte protease Granzyme B (GZMB) can promote apoptosis through direct processing and activation of members of the caspase family. Granzyme B also functions as processing protease of cytokines, including interleukin (IL)-18 and IL-1a, and extracellular matrix proteins, including fibronectin and various proteoglycans. Plasma Granzyme B concentrations were significantly higher in patients with Atopic dermatitis (AD) and psoriasis than in healthy controls, which indicated that Granzyme B may play an important role in the induction of intractable itch and dermatitis in AD. |
This test kit is a solid phase sandwich Enzyme Linked-Immuno-Sorbent Assay (Sandwich ELISA). The Haptoglobin ELISA kit is to be used to detect and quantify protein levels of endogenous Haptoglobin. The assay recognizes human Haptoglobin. An antibody specific for Haptoglobin has been pre-coated onto the microwells. The Haptoglobin protein in samples is captured by the coated antibody after incubation. Following extensive washing, another antibody of biotinylated specific for human Haptoglobin is added to detect the captured human Haptoglobin protein. For signal development, Streptavidin-HRP is added, followed by Tetramethyl-benzidine (TMB) reagent. Solution containing sulfuric acid is used to stop color development and the color intensity which is proportional to the quantity of bound protein is measurable at 450nm with the correction wavelength set at 630 nm.
Core Diagnostic Capabilities
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