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| Catalog: | C-EL-1989T |
| Product Type: | Test kit |
| Size: | 96 tests |
| Principle: | Sandwich ELISA |
| Species: | Human |
| Detection range: | 31.25-2000 pg/mL |
| Sensitivity: | 7.0 pg/mL |
| Sample type: | Serum, Plasma |
| Test type: | Quantitative |
| Analysis mode: | ELISA |
| Storage: | All the reagents are stored at 2-8℃. Refer to the protocol for further storage instructions. |
| Synonyms:: | DIR1, FK506 binding protein like, FKBPL, NG7, WISP39 |
| Application: | Factor XII (FXII, Hageman factor) is a 80kD, single chain glycoprotein that circulates in blood as an inactive zymogen. FXII plays an important role in blood coagulation, fibrinolysis, and kinin generation. When plasma comes into contact with negatively charged surfaces such as glass, kaolin, or dextran sulfate, FXII is bound to the surface and undergoes limited proteolysis by plasma kallikrein, resulting in two active enzyme forms, ɑ-FXIIa and β-FXIIa. Hereditary deficiencies in FXII are not associated with spontaneous or excessive bleeding. FXII inhibition also have protective role against arterial thrombosis and stroke, suggesting that FXII may be a target for antithrombotic therapy. This kit is used to quantify FXII in vivo. |
This test kit is a solid phase sandwich Enzyme Linked-Immuno-Sorbent Assay (Sandwich ELISA). The FKBPL ELISA kit is to be used to detect and quantify protein levels of endogenous FKBPL. The assay recognizes human FKBPL. An antibody specific for FKBPL has been pre-coated onto the microwells. The FKBPL protein in samples is captured by the coated antibody after incubation. Following extensive washing, another antibody specific for FKBPL is added to detect the captured FKBPL protein. For signal development, horseradish peroxidase (HRP)-conjugated antibody is added, followed by Tetramethyl-benzidine (TMB) reagent. Solution containing sulfuric acid is used to stop color development and the color intensity which is proportional to the quantity of bound protein is measurable at 450nm with the correction wavelength set at 630 nm.
Core Diagnostic Capabilities
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