HTGL Serum ELISA

HTGL (hepatic triacylglycerol lipase / hepatic triglyceride lipase) is a secreted glycoprotein and known as a lipolytic enzyme and is also called hepatic lipase (HL). HTGL has an important role in lipoprotein metabolism as a lipolytic enzyme that hydrolyzes triglycerides (TG) and phospholipids in chylomicron remnants, intermediate-density lipoproteins (IDL) and high-density lipoproteins (HDL). It has been reported that hypercholesterolemia or triglyceridemia is observed and very-low-density lipoproteins (VLDL), chylomicron remnants, IDL, TG-rich low-density lipoproteins (LDL) and HDL are accumulated in patients with deficiency of HTGL. HTGL is synthesized by hepatocytes and bound to heparin sulfate proteoglycans at the surface of liver sinusoidal capillaries. This ELISA kit can detect HTGL in serum and plasma regardless of administration of heparin that is conventionally required for the measurement.