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Granulin ELISA Kit

  • Product Information
  • Description
Catalog: C-EL-1788T
Product Type: Test kit
Size: 96 tests
Principle: Solid Phase Sandwich ELISA
Conjugation: HRP
Species: Human
Detection range: 78.13-5000 pg/mL
Sensitivity: 40.62 pg/mL
Specificity: Recognizes both recombinant and natural Human Granulin
Sample type: Serum
Test type: Quantitative
Analysis mode: ELISA
Shipping: This ELISA Kit is shipped at ambient temperature.
Storage: 2-8℃
Full name: Granulin Precursor

This Granulin ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human Granulin protein in Serum . It contains recombinant Human Granulin, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The precursor protein, progranulin, is also called Proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling. Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth. Granulin expression inhibited Tat transactivation, and tethering experiments showed that this effect was due, at least in part, to a direct action on cyclin T1 in the absence of Tat.

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