GPC3 polyclonal antibody

The cell surface heparin sulfate proteoglycan is replaced by a variable number of heparin sulfate chains with a membrane-associated protein core. The members of the glycosyl-related global membrane proteoglycan family (GRIPS) contain a core protein that is fixed on the cell plasma membrane through glycosylphosphatidylinositol linkages. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and can induce apoptosis in certain cell types. Deletion mutations in this gene are related to Simpson-Gorabi-Bemel syndrome, also known as Simpson malformation syndrome. Alternative splicing results in multiple transcript variations.