Catalog: | C0129A |
Product Type: | Antibody |
Reactivity: | H,M |
Analysis mode: | IHC,ELISA |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Concentration: | 2.28 mg/mL |
Storage: | -20℃ |
Buffer: | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
Purification method: | Antigen affinity purification |
Application: | Cancer, Epigenetics and Nuclear Signaling |
Conjugation: | Unconjugated |
Immunogen: | FOLR1 |
Swiss port: | P15328 |
Gene accession: | NP000793 |
Celluar localization: | Cell membrane, Secreted |
FOLR1 is a 38-kDA glycoprotein belonging to the folate receptor family. The receptor binds folic acid and a reduced folic acid derivative and mediates the delivery of 5-methyltetrahydrofolic acid into the cell interior. FOLR1 is a secretory protein anchored to the cell membrane by a glycosylphosphatidylinositol connection or in a soluble form. FOLR1 expression is usually confined to the root tip surface of the lung, kidney, and choroid plexus epithelium, but is overexpressed in a variety of solid tumors such as ovarian cancer, non-small cell lung cancer, breast cancer, renal cancer, and high-grade osteosarcoma.
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