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FOLR1 polyclonal antibody

  • Product Information
  • Description
Catalog: C0129A
Product Type: Antibody
Reactivity: H,M
Analysis mode: IHC,ELISA
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Concentration: 2.28 mg/mL
Storage: -20℃
Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Purification method: Antigen affinity purification
Application: Cancer, Epigenetics and Nuclear Signaling
Conjugation: Unconjugated
Immunogen: FOLR1
Swiss port: P15328
Gene accession: NP000793
Celluar localization: Cell membrane, Secreted

FOLR1 is a 38-kDA glycoprotein belonging to the folate receptor family. The receptor binds folic acid and a reduced folic acid derivative and mediates the delivery of 5-methyltetrahydrofolic acid into the cell interior. FOLR1 is a secretory protein anchored to the cell membrane by a glycosylphosphatidylinositol connection or in a soluble form. FOLR1 expression is usually confined to the root tip surface of the lung, kidney, and choroid plexus epithelium, but is overexpressed in a variety of solid tumors such as ovarian cancer, non-small cell lung cancer, breast cancer, renal cancer, and high-grade osteosarcoma.

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Diagnostic Development

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