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| Catalog: | C-FC-4742A |
| Product Type: | FCM Antibody |
| Size: | 0.1 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | mouse splenocytes |
| Recommended dilution: | This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
| Analysis mode: | FC |
| Host: | Hamster |
| Isotype: | IgG |
| Alternate names: | AI504783, CD3, CD3e, CD3epsilon, CD3ε, T3e |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | H-2Kb-specific murine cytotoxic T-lymphocyte (CTL) clone BM10-37 |
| Genn_ID: | 12501 |
| Gene accession: | BC098236 |
| Gene symbol: | Cd3e |
| Buffer: | PBS with 0.1% sodium azide. |
CD3 is a multimeric protein associated with the T-cell receptor (TCR) to form a complex involved in antigen recognition and signal transduction (PMID: 15885124). CD3 is composed of CD3γ, δ, ε, and ζ chains (PMID: 1826255). It is expressed by thymocytes in a developmentally regulated manner, T cells, and some NK cells (PMID: 3289580). The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction (PMID: 11985657).
Core Diagnostic Capabilities
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