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| Catalog: | C-FC-4727A |
| Product Type: | FCM Antibody |
| Size: | 0.5 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | human peripheral blood lymphocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 μl per 10^6 cells in a 100 µl suspension or 5 μl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | IgG2a |
| Alternate names: | Cd11a, integrin alpha L, Itgal, LFA 1, Ly 15, Ly 21 |
| Storage: | 2-8°C |
| Purification method: | The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Immunogen: | C57BL/6 mouse splenic secondary cytotoxic T cells |
| Genn_ID: | 3683 |
| Gene accession: | BC008777 |
| Gene symbol: | ITGAL |
| Buffer: | PBS with 0.1% sodium azide. |
CD11a, also known as integrin αL or LFA-1α, is a 170-180 kDa transmembrane glycoprotein that forms a heterodimer with CD18 (PMID: 7027264; 1672643). CD11a/CD18 (LFA-1) is expressed by all leukocytes and mediates cell adhesion through interactions with its ligands, intercellular adhesion molecule 1 (ICAM-1), ICAM-2, and ICAM-3 (PMID: 7479767). CD11a/CD18 also functions in lymphocyte costimulatory signaling (PMID: 1972160).
Core Diagnostic Capabilities
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