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| Catalog: | C-FC-4722A |
| Product Type: | FCM Antibody |
| Size: | 0.5 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | mouse splenocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Hamster |
| Isotype: | IgG |
| Alternate names: | alpha E1, alpha M290, aM290, CD103, Integrin alpha M290, Integrin alpha-E, Itgae |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL) |
| Genn_ID: | 16407 |
| Gene accession: | BC150690 |
| Gene symbol: | Itgae |
| Buffer: | PBS with 0.1% sodium azide. |
CD103, also known as integrin alpha-E (ITGAE) or integrin alpha-IEL, is a type I transmembrane integrin protein that binds integrin beta 7 to form Integrin alpha-E beta-7 which is a receptor for E-cadherin and mediates adhesion of T lymphocytes to epithelial cells (PMID: 7969453; 8468482). CD103 is expressed on intraepithelial lymphocyte (IEL) T cells (both alpha/beta T cells and gamma/delta T cells), some peripheral regulatory T cells (Tregs), lamina propria T cells, and a subset of dendritic cells in the gut mucosa and mesenteric lymph nodes (PMID: 12242333; 15608520; 16216890).
Core Diagnostic Capabilities
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