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| Catalog: | C-FC-4714A |
| Product Type: | FCM Antibody |
| Size: | 4 µl/test |
| Reactivity: | Human |
| Positive FC: | Human peripheral blood lymphocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | Mouse IgG1 kappa |
| Alternate names: | 5 NT, 5 nucleotidase, 5' nucleotidase, ecto (CD73), CD73, E5NT, Ecto 5 nucleotidase, eN, eNT, NT, NT5, NT5E, NTE |
| Storage: | 2-8°C |
| Purification method: | The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Immunogen: | Cells |
| Genn_ID: | 4907 |
| Gene accession: | BC015940 |
| Gene symbol: | NT5E |
| Buffer: | PBS with 0.1% sodium azide. |
CD73, also known as ecto-5'-nucleotidase (5'-NT), is a 70-kDa, glycosyl-phosphatidylinositol-linked membrane-bound glycoprotein found in most tissues (PMID: 18404475; 20179192). CD73 is en ecto-enzyme which catalyzes the dephosphorylation of AMP and other nucleoside monophosphates (PMID: 9553767). In the human immune system, CD73 is expressed on subsets of T and B cells, on germinal center follicular dendritic cells, and on thymic medullary reticular fibroblasts and epithelial cells (PMID: 2137649; 9553767). CD73 is highly expressed in many human solid tumors is closely involved in cancer progression (PMID: 20179192).
Core Diagnostic Capabilities
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