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| Catalog: | C-FC-4683A |
| Product Type: | FCM Antibody |
| Size: | 20 µl/test |
| Reactivity: | Human, Non-human primates |
| Positive FC: | human peripheral blood granulocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | Mouse IgG1 |
| Alternate names: | Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, ANPEP, AP M, AP N, APN, CD13, gp150, hAPN, LAP1, Microsomal aminopeptidase, p150, PEPN |
| Storage: | 2-8°C |
| Purification method: | The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Immunogen: | Human AML cells |
| Genn_ID: | 290 |
| Gene accession: | BC058928 |
| Gene symbol: | ANPEP |
| Buffer: | PBS with 0.1% sodium azide. |
CD13, also named as APN, ANPEP (aminopeptidase N) or PEPN, is a heavily glycosylated, ~150-240 kDa, type-II membrane, expressed by most cells of myeloid origin including monocytes, macrophages, granulocytes, and their hematopoietic precursors. It is also abundantly expressed in the brush border of epithelial cells from renal proximal tubules and small intestine, in prostatic epithelial cells, in bile duct canaliculi, in mast cells, and, in some cases, in fibroblasts and smooth muscle cells. CD13 is a multifunctional protein and plays varying roles in cell migration, cell proliferation, cell differentiation and so on. CD13 participates in angiogenesis generating and modulating angiogenic signals, and can be a marker of angiogenic vessels. CD13 is also a pan-myeloid marker, present on mature granulocytes and monocytes. (PMID: 8805662, 10098327, 18603472, 18097955, 17897790, 17888402, 21339174)
Core Diagnostic Capabilities
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