ERBB3 polyclonal antibody

V-erb-b2 erythrocyte leukemia virus oncogene homolog 3 (ErbB-3, HER3) is a member of the EGF receptor tyrosine kinase family, including EGFR, Neu, ErbB-3 and ErbB-4, which are used in many cancers Often overexpressed in. These family members form homodimers or heterodimers when ligands bind to mediate cell growth. ErbB-3 binds and is activated by neuregulins and NTAK. It forms a heterodimer with other ErbB receptors. ErbB-3 is mainly expressed in epithelial and brain tissues, and is overexpressed in a subset of human breast tumors.