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| Catalog: | C0091A |
| Product Type: | Antibody |
| Reactivity: | H,M,R |
| Analysis mode: | WB,ELISA |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 0.7 mg/mL |
| Storage: | -20℃ |
| Buffer: | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification method: | Antigen affinity purification |
| Application: | Cancer, Epigenetics and Nuclear Signaling |
| Conjugation: | Unconjugated |
| Immunogen: | ELAC2 |
| Swiss port: | Q9BQ52 |
| Gene accession: | BC001939 |
| Celluar localization: | Nucleus |
| Tissue specificity: | Widely expressed. Highly expressed in heart, placenta, liver, skeletal muscle, kidney, pancreas, testis and ovary. Weakly expressed in brain, lung, spleen, thymus, prostate, small intestine, colon and leukocytes. |
The synonym is HPC2 (heredity prostate cancer protein 2). The protein catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 and its nuclear partner forkhead box H1, and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer.
Diagnostic Development
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