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EGFR polyclonal antibody

  • Product Information
  • Description
Catalog: C0002A
Product Type: Antibody
Reactivity: H,M
Analysis mode: IHC,IF
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Concentration: 0.57 mg/mL
Storage: -20℃
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4
Purification method: Antigen affinity purification
Application: Cancer, Signal Transduction
Conjugation: Unconjugated
Immunogen: EGFR
Swiss port: P00533
Genn_ID: 1956
Celluar localization: Secreted and Cell membrane, Endoplasmic reticulum membrane, Golgi apparatus membrane, Nucleus membrane, Endosome, Endosome membrane, Nucleus
Tissue specificity: Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.

EGFR is a cell-surface receptor for members of the epidermal growth factor family of extracellular protein ligands. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. The gene encodes a 170 kDa membrane-associated glycoprotein. EGFR plays a critical role in cancer development and progression, including cell proliferation, apoptosis, angiogenesis, and metastatic spread. Mutations in this gene are associated with colorectal cancer.

Verification Code

Diagnostic Development

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