Catalog: | C0436A |
Product Type: | Antibody |
Reactivity: | H,M,R |
Analysis mode: | IHC,ELISA |
Host: | Rabbit |
Clonality: | Polyclonal |
Isotype: | IgG |
Concentration: | 1.02 mg/mL |
Storage: | -20℃ |
Buffer: | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
Purification method: | Antigen affinity purification |
Application: | Cancer, Immunology |
Conjugation: | Unconjugated |
Immunogen: | CXCL1 |
Swiss port: | P09341 |
Gene accession: | NP001502 |
Celluar localization: | Secreted |
CXCL1 (C-X-C Motif Chemokine Ligand 1) is a protein coding gene. Diseases associated with CXCL1 include melanoma and bacterial meningitis. The related pathways include peptide ligand binding receptor and chemokine superfamily pathway: human/mouse ligand-receptor interaction. The GO annotations associated with this gene include receptor binding and chemokine activity. An important by-product of this gene is CXCL2. This antibacterial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the g protein-coupled receptor CXC receptor 2. This protein plays a role in inflammation and acts as a chemotactic agent for neutrophils. The abnormal expression of this protein is related to the growth and progression of certain tumors. A naturally occurring processed form of this protein increases chemotactic activity. The alternation of splicing leads to coding and non-coding mutations of the gene.
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