USA: 
Europe: 
Email: 
Consultation
| Catalog: | C-FC-4660A |
| Product Type: | FCM Antibody |
| Size: | 5 µl/test |
| Reactivity: | Mouse |
| Positive FC: | BALB/c mouse splenocytes |
| Recommended dilution: | This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
| Analysis mode: | IF,FC |
| Host: | Rat |
| Isotype: | IgG2a |
| Alternate names: | BB154331, CD8 antigen, alpha chain, Cd8a, Ly 2, Ly 35, Ly B, Lyt 2 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Spleen cells or thymocyte membranes |
| Genn_ID: | 12525 |
| Gene accession: | BC030679 |
| Gene symbol: | Cd8a |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084).
Core Diagnostic Capabilities
Follow Us -
Copyright © 2025 Creative Biogene. All rights reserved.
