CoraLite®647 Anti-Mouse CD62L (L-Selectin) (MEL-14)

L-selectin, also known as SELL or CD62L, is a member of the selectin family of adhesion molecules that includes E-selectin and P-selectin (PMID: 2663882, 2473156, 1382078). L-selectin is a protein with the calculated molecular mass of 42 kDa but actually 95-105 kDa on neutrophils and 74 kDa on lymphocytes because of the highly glycosylation (PMID: 1694883, 1695155). L-selectin is expressed on the surface of most leukocytes, including lymphocytes, neutrophils, monocytes, eosinophils, hematopoietic progenitor cells, and immature thymocytes (PMID: 1694883, 1688580). L-selectin mediates the binding of lymphocytes to high endothelial venules (HEV) of peripheral lymph nodes through interactions with a constitutively expressed ligand, and are also involved in lymphocyte, neutrophil, and monocyte attachment to endothelium at sites of inflammation (PMID: 1382078).