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| Catalog: | C-FC-4656A |
| Product Type: | FCM Antibody |
| Size: | 5 µl/test |
| Reactivity: | Mouse |
| Positive FC: | mouse splenocytes |
| Recommended dilution: | This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | IgM |
| Alternate names: | CD49B, DX5, integrin alpha 2, Itga2 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | NK cells isolated from C57BL/6 mice |
| Genn_ID: | 16398 |
| Gene accession: | BC065139 |
| Gene symbol: | Itga2 |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
Integrins are a large family of α/β transmembrane receptors playing a key role in cell-cell interactions and cell adhesion to the extracellular matrix (PMID: 30374344). CD49b, also known as integrin alpha-2, is a 150 kDa transmembrane glycoprotein expressed on a wide variety of cell types including platelets, megakaryocytes, NK cells, NKT cells, neutrophils, and long-term activated T cells (PMID: 18802064; 2415516). Integrin alpha-2/beta-1 (also known as VLA-2) is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin (PMID: 2557634). It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and CLG gene expression, force generation and organization of newly synthesized extracellular matrix.
Core Diagnostic Capabilities
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