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| Catalog: | C-FC-4653A |
| Product Type: | FCM Antibody |
| Size: | 5 µl/test |
| Reactivity: | Mouse |
| Positive FC: | SJL mouse splenocytes |
| Recommended dilution: | This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | IgG2a |
| Alternate names: | B220, Cd45, CD45R, loc, Ly 5, Lyt 4, Ptprc, T200 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | SJL mouse thymocytes and splenocytes |
| Genn_ID: | 19264 |
| Gene accession: | BC028512 |
| Gene symbol: | Ptprc |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
CD45, also known as protein tyrosine phosphatase, receptor type C, is a type I transmembrane protein expressed on the surface of all haematopoietic cells with the exception of erythrocytes and platelets (PMID: 3489673; 28615666). CD45 is a pan-haematopoietic cell marker and has been shown to be essential for T- and B-cell activation and signalling (PMID: 9429890; 16378097). Allelic variants of mouse CD45, CD45.1 (Ly5.1) and CD45.2 (Ly5.1), have been established as a marker system to track haematopoietic cells following congenic mouse bone marrow transplants (PMID: 28615666). CD45.2 is the common form and is expressed by most of the established strains, while CD45.1 is found in only a few like the SJL mouse strain (PMID: 3489673).
Core Diagnostic Capabilities
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