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| Catalog: | C-FC-4648A |
| Product Type: | FCM Antibody |
| Size: | 5 µl/test |
| Reactivity: | Mouse |
| Positive FC: | mouse splenocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. |
| Analysis mode: | IF,FC |
| Host: | Rat |
| Isotype: | IgG2a |
| Alternate names: | Cd38, CD38 antigen, Cd38 rs1 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Mouse bone marrow pre-B cells |
| Genn_ID: | 12494 |
| Gene accession: | BC046312 |
| Gene symbol: | Cd38 |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
CD38, also known as ADP-ribosyl cyclase 1, is a type II transmembrane glycoprotein with a short N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites (PMID: 2319135). The extracellular domain of CD38 has bifunctional enzyme activities that catalyze synthesis of cyclic ADP ribose from nicotinamide adenine dinucleotide (NAD) and hydrolysis of cyclic ADP ribose to adenosine diphosphoribose (PMID: 10636863). CD38 is expressed on a variety of hematopoietic and non-hematopoietic cells and is involved in diverse processes such as generation of calcium-mobilizing metabolites, cell activation, and chemotaxis (PMID: 25938500).
Core Diagnostic Capabilities
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