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| Catalog: | C-FC-4647A |
| Product Type: | FCM Antibody |
| Size: | 5 µl/test |
| Reactivity: | Mouse |
| Positive FC: | mouse splenocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | Rat IgG2b |
| Alternate names: | AITR, CD357, Gitr, Tnfrsf18 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Mouse CD25+ CD4+ T cells |
| Genn_ID: | 21936 |
| Gene accession: | BC146517 |
| Gene symbol: | Tnfrsf18 |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
Glucocorticoid-induced TNFR-related protein (GITR), also known as CD357 or TNFRSF18, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is expressed constitutively at high levels in T regulatory cells (Treg cells) and plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells (PMID: 11812990). It is expressed at low levels on resting responder T cells. The expression of GITR on T cells can be upregulated upon activation (PMID: 15770698). GITR is activated by GITR ligand (GITRL) which is mainly expressed on APC. GITR-GITRL interactions could co-stimulate both responder T-cell functions and the suppressive functions of Treg cells (PMID: 16868552).
Core Diagnostic Capabilities
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