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| Catalog: | C-FC-4640A |
| Product Type: | FCM Antibody |
| Size: | 5 μl/test |
| Reactivity: | Mouse |
| Positive FC: | human red blood cells |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 20 µl per 10^6 cells in a 100 µl suspension or 20 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | Rat IgG1, kappa |
| Alternate names: | CD223, LAG 3, Lag3, Ly66, lymphocyte activation gene 3 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Murine CD223-Ig fusion protein |
| Genn_ID: | 2993 |
| Gene accession: | BC005319 |
| Gene symbol: | GYPA |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
Lymphocyte activation gene 3 protein (LAG-3), also known as CD223, is a type I transmembrane protein belonging to the immunoglobulin superfamily (PMID: 1692078). It is a CD4-related molecule that binds MHC class II with high affinity (PMID: 1692078; 9159144). LAG-3 is expressed on activated T and NK cells. Besides, natural CD4(+)CD25(+) Tregs express LAG-3 upon activation (PMID: 15485628). LAG-3 negatively regulates T-cell function and homeostasis, and contributes to the suppressor activity of Tregs (PMID: 14644131; 15485628).
Core Diagnostic Capabilities
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