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| Catalog: | C-FC-4630A |
| Product Type: | FCM Antibody |
| Size: | 5 µl/test |
| Reactivity: | Mouse |
| Positive FC: | HeLa cells |
| Recommended dilution: | IF : 1:50-1:500 This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood. |
| Analysis mode: | IF,FC |
| Host: | Rat |
| Isotype: | IgG2a |
| Alternate names: | AI196048, CD107a, Lamp 1, Lamp1 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Plasma membrane fraction of mouse embryo NIH/3T3 cell line |
| Genn_ID: | 3916 |
| Gene accession: | BC006345 |
| Gene symbol: | LAMP1 |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
LAMP1 (CD107a) is a heavily glycosylated membrane protein enriched in the lysosomal membrane. LAMP1 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP1 is expressed largely in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane (PMID: 16168398). Elevated LAMP1 expression at the cell surface has also been detected during platelet and granulocytic cell activation, as well as in some tumor cells (PMID: 29085473). LAMP1 functions to provide selectins with carbohydrate ligands. This protein has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells and may also play a role in tumor cell differentiation and metastasis (PMID: 18835598; 29085473; 9426697).
Core Diagnostic Capabilities
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