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| Catalog: | C-FC-4628A |
| Product Type: | FCM Antibody |
| Size: | 5 μl/test |
| Reactivity: | Human |
| Positive FC: | human peripheral blood |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | IgG2b |
| Alternate names: | B7 H, B7 H1, B7 homolog 1, B7H1, CD274, CD274 molecule, PD L1, PDCD1 ligand 1, PDCD1L1, PDCD1LG1, PDL1, Programmed death ligand 1 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Full length human PD-L1 |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
Programmed cell death ligand 1 (PD-L1, CD274, or B7-H1), is the first member of B7 family to be discovered. B7 family molecules are type I transmembrane proteins belonging to the immunoglobulin superfamily. In concert with their CD28 family receptors, the B7s are key regulators of the adaptive immune response. PD-L1 is suggested as a negative regulator of T and B cell, and plays important role in mediating tolerance of lymphocytes to self-antigens. It is also involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PD-1-independent manner.
Core Diagnostic Capabilities
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