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| Catalog: | C-FC-4621A |
| Product Type: | FCM Antibody |
| Size: | 5 µl/test |
| Reactivity: | Human |
| Positive FC: | human peripheral blood lymphocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 μl per 10^6 cells in a 100 µl suspension or 5 μl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | Mouse IgG1, kappa |
| Alternate names: | Activation B7 1 antigen, B7, B7 1, BB1, CD28LG, CD28LG1, CD80, CD80 molecule, CTLA 4 counter receptor B7.1, LAB7 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | N/A |
| Genn_ID: | 975 |
| Gene accession: | BC002978 |
| Gene symbol: | CD81 |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
CD80 (also known as B7-1) is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B. (PMID: 7545666; 12015893; 16920215)
Core Diagnostic Capabilities
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