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| Catalog: | C-FC-4586A |
| Product Type: | FCM Antibody |
| Size: | 5 µl/test |
| Reactivity: | Human |
| Positive FC: | human peripheral blood monocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | IgG1 |
| Alternate names: | CD11C, Integrin alpha X, ITGAX, Leu M5, SLEB6 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Rheumatoid synovial cells and human monocytes |
| Genn_ID: | 7132 |
| Gene accession: | BC010140 |
| Gene symbol: | TNFRSF1A |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11c, also known as integrin αX, is a type I transmembrane glycoprotein present on a variety of cells, including monocytes/macrophages, granulocytes, a subset of B cells, NK cells and dendritic cells (PMID: 2897326; 1680915; 1694698; 17389580). As a result of its high level of expression on most dendritic cells, CD11c is typically considered to be a marker of conventional dendritic cells (PMID: 27119555). CD11c forms an α/β heterodimer with CD18 (integrin β2). CD11c/CD18 acts a receptor for fibrinogen and is important in monocyte adhesion and chemotaxis (PMID: 1671533).
Core Diagnostic Capabilities
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