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| Catalog: | C-FC-4578A |
| Product Type: | FCM Antibody |
| Size: | 5 μl/test |
| Reactivity: | Human |
| Positive FC: | NIH/3T3 cells |
| Recommended dilution: | IF : 1:50-1:500 This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | IgG1 |
| Alternate names: | CD107b, LAMP 2, LAMP2, LAMPB, LGP110 |
| Storage: | 2-8°C |
| Purification method: | Protein G purification |
| Immunogen: | Human adherent peripheral blood cells |
| Genn_ID: | 16784 |
| Gene accession: | BC138718 |
| Gene symbol: | Lamp2 |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
LAMP2 (CD107b) is a Lysosomal membrane glycoprotein. LAMP2 is extensively glycosylated with asparagine-linked oligosaccharides which protect it from intracellular proteolysis (PMID: 10521503). Although LAMP-2 is localized primarily in the endosome-lysosomal membrane of cells, it is also found on the plasma membrane under certain circumstances, e.g., after platelet activation, during granulocytic differentiation and activation, and in some tumor cells (PMID: 12221139). LAMP is involved in lysosomal stability and autophagy (PMID: 12221139). This glycoprotein provides selectins with carbohydrate ligands. LAMP2 may plays a role in tumor cell metastasis (PMID 9426697).
Core Diagnostic Capabilities
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