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| Catalog: | C-FC-4538A |
| Product Type: | FCM Antibody |
| Size: | 5 µl/test |
| Reactivity: | Mouse |
| Positive FC: | mouse splenocytes |
| Recommended dilution: | This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | Rat IgG1, kappa |
| Alternate names: | ACT35, CD134, Ly 70, Ox40, Tnfrsf4, Txgp1, TXGP1L |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | N/A |
| Genn_ID: | 22163 |
| Gene accession: | BC065782 |
| Gene symbol: | Tnfrsf4 |
| Buffer: | PBS with 0.1% sodium azide and 0.5% BSA, pH 7.3. |
CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).
Core Diagnostic Capabilities
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