CD47 polyclonal antibody

CD47, also known as integrin-related protein (IAP), is a member of the immunoglobulin superfamily and contains five transmembrane attachments. CD47 is severely glycosylated and is widely expressed in hematopoietic and non-hematopoietic cells. CD47 interacts with several membrane integrins and also acts as a receptor for thrombospondin (THBS1). It is involved in a series of cellular processes, including apoptosis, proliferation, adhesion and migration. CD47 also functions as a ligand for signal regulatory protein-α (SIRPα). After SIRP enzyme binds to CD47, it initiates a signal cascade to inhibit phagocytosis.