CD146 polyclonal antibody

CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, was originally identified as a biomarker of melanoma progression. It is a transmembrane glycoprotein and belongs to the immunoglobulin (Ig) superfamily. Structurally, it consists of five Ig regions, a transmembrane region and a cytoplasmic region. In normal adult tissues, CD146 is mainly expressed through vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein that affects vascular endothelial cell activity and angiogenesis, and has been used as a marker for circulating endothelial cells (CECs).