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CD146 polyclonal antibody

  • Product Information
  • Description
Catalog: C0429A
Product Type: Antibody
Reactivity: M,R
Analysis mode: IHC
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Concentration: 0.61 mg/mL
Storage: -20℃
Buffer: PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
Purification method: Antigen affinity purification
Application: Immunology, Signal Transduction, Cancer, Stem Cells, Cardiovascular
Conjugation: Unconjugated
Immunogen: CD146
Swiss port: Q9EPF2
Genn_ID: 78967
Celluar localization: Cell membrane, Membrane
Tissue specificity: Expressed in most organs.

CD146, also known as melanoma cell adhesion molecule (MCAM) or MUC18, was originally identified as a biomarker of melanoma progression. It is a transmembrane glycoprotein and belongs to the immunoglobulin (Ig) superfamily. Structurally, it consists of five Ig regions, a transmembrane region and a cytoplasmic region. In normal adult tissues, CD146 is mainly expressed through vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein that affects vascular endothelial cell activity and angiogenesis, and has been used as a marker for circulating endothelial cells (CECs).

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Diagnostic Development

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