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BRCA2 polyclonal antibody

  • Product Information
  • Description
Catalog: C0128A
Product Type: Antibody
Reactivity: H,R
Analysis mode: WB,IHC,IF
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/mL
Storage: -20℃
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4
Purification method: Antigen affinity purification
Application: Cancer, Epigenetics and Nuclear Signaling
Conjugation: Unconjugated
Immunogen: BRCA2
Swiss port: P51587
Genn_ID: 675
Celluar localization: Nucleus, Cytoskeleton
Tissue specificity: Highest levels of expression in breast and thymus, with slightly lower levels in lung, ovary and spleen.

Genetic mutations in the BRCA1 and BRCA2 genes increase the lifetime risk of breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintaining genomic stability, particularly homologous recombination pathways for double-stranded DNA repair. BRCA2 proteins contain multiple copies of the 70 AA motif known as the BRC motif, which mediate binding to the RAD51 recombinase, which is involved in DNA repair. BRCA2 is considered a tumor suppressor gene because tumors with BRCA2 mutations often present with wild-type allelic heterozygosity loss.

Verification Code

Diagnostic Development

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