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BRCA1 polyclonal antibody

  • Product Information
  • Description
Catalog: C0182A
Product Type: Antibody
Analysis mode: WB, IHC, IF, ELISA
Species specificity: Human
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Concentration: 300 μg/mL
Storage: -20℃
Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3
Purification method: Antigen affinity purification
Conjugation: Unconjugated
Immunogen: BRCA1
Genn_ID: 672
Gene accession: BC115037

BRCA1 plays a central role in DNA repair by promoting the cell's response to DNA repair. BRCA1-BARD1 heterodimer coordinates a variety of cellular pathways, such as DNA damage repair, ubiquitination and transcriptional regulation, to maintain genome stability. BRCA1 acts by mediating the ubiquitin E3 ligase activity required for its tumor suppressor function. It participates in the transcriptional regulation of P21 in response to DNA damage. BRCA1 is required for FANCD2 to target DNA damage sites. It may play a role in transcriptional regulation. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. The antibody is specific for BRCA1. BRCA1 seems to produce multiple splice variants.

Verification Code

Diagnostic Development

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