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BRCA1 polyclonal antibody

  • Product Information
  • Description
Catalog: C0126A
Product Type: Antibody
Reactivity: H,R
Analysis mode: WB,IHC-p,IF,ELISA
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Concentration: 1 mg/mL
Storage: -20℃
Buffer: PBS with 0.05% Proclin300 and 50% glycerol, pH7.4
Purification method: Antigen affinity purification
Application: Cancer, Cell Biology, Epigenetics and Nuclear Signaling
Conjugation: Unconjugated
Immunogen: BRCA1
Swiss port: P38398
Celluar localization: Cytoplasm, Nucleus
Tissue specificity: Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines.

The gene encodes a nuclear phosphorylated protein that plays a role in maintaining genomic stability and also in tumor suppression. The encoded protein binds to other tumor suppressors, DNA damage sensors, and signal transducers to form a large polysubunit protein complex called the BRCA1 associated genomic monitoring complex (BASC).The protein plays a role in transcription, DNA repair, double strand break, and recombination. About 40 percent of inherited breast cancers and more than 80 percent of inherited breast and ovarian cancers are linked to mutations in the gene.

Verification Code

Diagnostic Development

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