BCR polyclonal antibody

The mutual translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myeloid leukemia. The breakpoint on chromosome 22 of this translocation is located in the BCR gene. The translocation produces a fusion protein that is encoded by the BCR and ABL gene sequences located at the breakpoint of chromosome 9. Although the BCR-abl fusion protein has been extensively studied, the function of the normal BCR gene product is still unclear. The protein has serine/threonine kinase activity and is the gtpa-activating protein of p21rac.