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| Catalog: | C0349A |
| Product Type: | Antibody |
| Reactivity: | H,M,R |
| Analysis mode: | WB,IHC,ELISA |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 0.5 mg/mL |
| Storage: | -20℃ |
| Buffer: | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification method: | Affinity purification |
| Application: | Cancer, Cell Biology, Metabolism, Signal Transduction |
| Conjugation: | Unconjugated |
| Immunogen: | BCL10 |
| Swiss port: | O95999 |
| Gene accession: | BC053617 |
| Celluar localization: | Cytoplasm, Perinuclear region, Membrane raft |
| Tissue specificity: | Ubiquitous. |
This gene is identified by translocation in a case of mucosal associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains the caspase recruitment domain (CARD), which can induce apoptosis and activate NF-kappaB. It is reported that this protein can interact with other card domain proteins including CARD9, 10, 11 and 14, which are considered to be upstream regulators of NF-kappaB signaling. This protein was found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma.
Diagnostic Development
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