Bcl-XL monoclonal antibody

BCL2L1 is a member of the BCL-2 protein family. BCL2L1 is expressed as three isomers Bcl-X(L), Bcl-X(s) and Bcl-X(beta), located outside the mitochondrial membrane. The Bcl-XL subtype is a protein containing 233 amino acids and is an inhibitor of apoptosis. Bcl-XL can form heterodimers with BAX, BAK or BCL2, while the heterodimers with BAX do not seem to have anti-apoptotic activity. The Bcl-XS isoform is a shorter variant with a length of 178 amino acids, lacking a region of 63 amino acids, and acts as an apoptosis activator.