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APC Anti-Rat CD8a Antibody

  • Product Information
  • Description
Catalog: C-FC-0800A
Product Type: FCM Antibody
Size: 25μg/50μg/100μg
Reactivity: Rat
Analysis mode: FCM
Host: Mouse
Isotype: Mouse IgG1, κ
Alternate names: T-cell surface glycoprotein CD8 alpha chain,CD8A,T-lymphocyte differentiation antigen T8/Leu-2,MAL
Form: Liquid
Shipping: Biological ice pack at 4℃
Storage: 2-8℃
Conjugation: APC
Buffer: PBS with 0.05% Proclin300, 1% BSA
Swiss port: P07725
Clone NO.: OX-8
Recommended use: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results or refer to the dilution we used in the experiment.

CD8a is a 32 kD glycoprotein also known as T8, Lyt2, Ly-2, and CD8α. CD8a is a member of the immunoglobulin superfamily expressed on most thymocytes, subset of mature T cells, most NK cells, macrophages, and some activated CD4+ T cells (not resting). CD8a forms heterodimers with the CD8β chain (CD8b) on the surface of most thymocytes, while mature peripheral T lymphocytes express almost exclusively the CD8 αβ heterodimer. Intestinal intraepithelial lymphocytes express CD8a without CD8b. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 participates in T cell activation through its association with the T cell receptor complex and protein tyrosine kinase lck (p56lck).

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