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APC Anti-Mouse CD54 Antibody

  • Product Information
  • Description
Catalog: C-FC-0727A
Product Type: FCM Antibody
Size: 25μg/50μg/100μg
Reactivity: Mouse
Analysis mode: FCM
Host: Rat
Isotype: Rat IgG2b, κ
Alternate names: Intercellular adhesion molecule 1,Icam1,MALA-2,MyD10,CD54,Icam-1
Form: Liquid
Shipping: Biological ice pack at 4℃
Storage: 2-8℃
Conjugation: APC
Buffer: PBS with 0.05% Proclin300, 1% BSA
Swiss port: P13597
Clone NO.: YN1/1.7.4
Recommended use: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results or refer to the dilution we used in the experiment.

CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

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