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| Catalog: | C-FC-4438A |
| Product Type: | FCM Antibody |
| Size: | 0.2 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | human peripheral blood mononuclear cells |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | IgG1 |
| Alternate names: | ACT35, CD134, Ly 70, Ox40, Tnfrsf4, Txgp1, TXGP1L |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Recombinant mouse OX-40-CD4 chimeric protein |
| Genn_ID: | 3604 |
| Gene accession: | BC006196 |
| Gene symbol: | TNFRSF9 |
| Buffer: | Phosphate based buffer with 0.09% sodium azide and 0.1% gelatin, pH 7.2. |
CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors (PMID: 2828930; 9766631). It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs) (PMID: 20307208). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule (PMID: 26215166). CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease (PMID: 26215166; 19426222).
Core Diagnostic Capabilities
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