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| Catalog: | C-FC-4388A |
| Product Type: | FCM Antibody |
| Size: | 10 µl/test |
| Reactivity: | Human |
| Positive FC: | mouse splenocytes |
| Recommended dilution: | This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | Mouse IgG1 kappa |
| Alternate names: | CD163, CD163 molecule, Hemoglobin scavenger receptor, M130, MM130, sCD163 |
| Storage: | 2-8°C |
| Purification method: | The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Immunogen: | Glycoprotein preparation from hairy cell leukemia spleen |
| Genn_ID: | 16414 |
| Gene accession: | BC145644 |
| Gene symbol: | Itgb2 |
| Buffer: | PBS with 0.1% sodium azide. |
CD163, also known as M130, is a membrane glycoprotein which belongs to the scavenger receptor superfamily (PMID: 8370408). It is an acute phase-regulated and signal-inducing macrophage protein expressed exclusively in monocytes and tissue macrophages (PMID: 11196644). CD163 mediates endocytosis of haptoglobin-haemoglobin complexes (PMID: 11196644). The uptake of haptoglobin by macrophages contributes to the recycling of iron and also to the inflammatory response (PMID: 22900885). Soluble CD163 (sCD163), as a result of ectodomain shedding during inflammatory activation of macrophages, circulates in blood and has been suggested as a plasma/serum marker for macrophage activity (PMID: 12570164).
Core Diagnostic Capabilities
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