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| Catalog: | C-FC-3547A |
| Product Type: | FCM Antibody |
| Size: | 50 µL/100 µL/1 mL |
| Reactivity: | Human |
| Specificity: | Human TrkBNo cross-reactivity in ELISA with Human Trk-A / NTRK1 / TRK Human Trk-C / NTRK3 / TRKC Mouse Trk-C / NTRK3 / TRKC |
| Analysis mode: | ELISA,ELISA(Cap),FCM |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Alternate names: | neurotrophic tyrosine kinase, receptor, type 2 |
| Form: | Liquid |
| Shipping: | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage: | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Purification method: | Protein A |
| Conjugation: | Unconjugated |
| Immunogen: | Recombinant Human Trk-B protein |
| Buffer: | 0.2 μm filtered solution in PBS |
| Application: | Receptor Tyrosine Kinases (RTKs); Cancer Drug Targets |
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation, and apoptosis of CNS neurons. Other neurotrophins include
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