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| Catalog: | C-FC-3358A |
| Product Type: | FCM Antibody |
| Size: | 25 Tests/100 Tests |
| Concentration: | 5 μl/Test, 0.1 mg/ml |
| Reactivity: | Human |
| Specificity: | Human ILT4 |
| Analysis mode: | FCM |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgG2b |
| Alternate names: | leukocyte immunoglobulin like receptor B2 |
| Form: | Liquid |
| Shipping: | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage: | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Purification method: | Protein A |
| Conjugation: | PE |
| Immunogen: | Recombinant Human LILRB2 / ILT4 / LIR-2 Protein |
| Buffer: | Aqueous solution containing 0.5% BSA and 0.09% sodium azide |
| Application: | ITIM/ITAM Immunoreceptors and Related Molecules |
ILT4, also known as LILRB2, is a member of the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). ILT4 gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. Multiple transcript variants encoding different isoforms have been found for the ILT4 gene. ILT4 is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity.
Core Diagnostic Capabilities
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