anti- FANCL antibody

Fanconi Anemia Complement Group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM and FANCN. Fanconi anemia is a genetically heterogeneous recessive genetic disease characterized by genetic instability of cells, hypersensitivity to DNA cross-linking agents, increased chromosome damage, and defects in DNA repair. The sequences of the members of the Fanconi anemia complementation group do not have similarities. They are connected to each other by assembling into a common nuclear protein complex. This gene encodes the complement group L protein. Alternative splicing results in two transcriptional variants encoding different isoforms.