anti- FANCA antibody

Fanconi Anemia Complement Group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ, FANCL, FANCM and FANCN. Fanconi anemia is a genetically heterogeneous recessive genetic disease characterized by genetic instability of cells, hypersensitivity to DNA cross-linking agents, increased chromosome damage, and defects in DNA repair. The sequences of the members of the Vanconi anemia complementation group do not have similarities; they are connected by assembling into a common nuclear protein complex. This gene encodes complementary group A protein. Alternative splicing results in multiple transcript variants encoding different subtypes. Mutations in this gene are the most common cause of Fanconi anemia.