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| Catalog: | C-FC-3225A |
| Product Type: | FCM Antibody |
| Size: | 25 Tests/100 Tests |
| Concentration: | 10 μl/Test, 0.1 mg/ml |
| Reactivity: | Human |
| Specificity: | Human CSF3R/G-CSFR |
| Analysis mode: | FCM |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Alternate names: | colony stimulating factor 3 receptor (granulocyte) |
| Form: | Liquid |
| Shipping: | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage: | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Purification method: | Protein A |
| Conjugation: | APC |
| Immunogen: | Recombinant Human G-CSFR / CD114 / CSF3R Protein |
| Buffer: | Aqueous solution containing 0.5% BSA and 0.09% sodium azide |
Granulocyte Colony Stimulating Factor Receptor (G-CSFR), also known as CD114, which belongs to the cytokine receptor superfamily, is a cell surface receptor for colony stimulating factor 3 (CSF3). It is a critical regulator of granulopoiesis. This type I membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type III (FNIII) domains in the extracellular region. Mutations in the G-CSF receptor leading to carboxy-terminal truncation transduce hyperproliferative growth responses, and are implicated in the pathological progression of severe congenital neutropenia (SCN) to acute myelogenous leukemia (AML). Additionally, autocrine/paracrine stimulation of G-CSFR may be important in the biology of solid tumors, including metastasis.
Core Diagnostic Capabilities
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