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| Catalog: | C-FC-3068A |
| Product Type: | FCM Antibody |
| Size: | 25 Tests/100 Tests |
| Concentration: | 10 μl/Test, 0.1 mg/ml |
| Reactivity: | Human |
| Specificity: | Human CD46 |
| Analysis mode: | FCM |
| Host: | Mouse |
| Clonality: | Monoclonal |
| Isotype: | IgG1 |
| Alternate names: | CD46 molecule, complement regulatory protein |
| Form: | Liquid |
| Shipping: | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage: | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Purification method: | Protein A |
| Conjugation: | FITC |
| Immunogen: | Recombinant Human CD46 protein |
| Buffer: | Aqueous solution containing 0.5% BSA and 0.09% sodium azide |
CD46, also known as Membrane Cofactor Protein (MCP), is a complement regulatory protein. CD46 is a type 1 membrane protein that plays an important inhibitory role in the complement system. CD46 is expressed in white blood cells, platelets, epithelial cells, and fibroblasts. Human CD46 shares 5% amino acid sequence identity with mouse and rat CD46. The importance of CD46 to complement regulation is underscored by the observation that genetic loss of CD46 leads to development of atypical hemolytic-uremic syndrome (aHUS), a disease characterized by uncontrolled complement activation. CD46 is implicated in the development and/or progression of selected cancer types.
Core Diagnostic Capabilities
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