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Anti-CD40 Antibody

  • Product Information
  • Description
Catalog: C-FC-3048A
Product Type: FCM Antibody
Size: 50 µL/100 µL
Reactivity: Human
Specificity: Human CD40
Analysis mode: FCM,ICC/IF
Host: Mouse
Clonality: Monoclonal
Isotype: IgG2b
Alternate names: CD40 molecule, TNF receptor superfamily member 5
Form: Liquid
Shipping: This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Purification method: Protein A
Conjugation: Unconjugated
Immunogen: Recombinant Human CD40 / TNFRSF5 protein
Buffer: 0.2 μm filtered solution in PBS
Application: Cancer Drug Targets

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

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