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Anti-CD40 Antibody (APC)

  • Product Information
  • Description
Catalog: C-FC-3040A
Product Type: FCM Antibody
Size: 25 Tests/100 Tests
Concentration: 5 μl/Test, 0.1 mg/ml
Reactivity: Rat
Specificity: Rat CD40
Analysis mode: FCM
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Alternate names: CD40 molecule, TNF receptor superfamily member 5
Form: Liquid
Shipping: This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage: This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Purification method: Protein A
Conjugation: APC
Immunogen: Recombinant Rat CD40/TNFRSF5 Protein
Buffer: Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Application: Cancer Drug Targets

CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

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