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Anti-CD16/FCGR3 Antibody

  • Product Information
  • Description
Catalog: C-FC-2910A
Product Type: FCM Antibody
Size: 50 µL/100 µL/200 µL
Reactivity: Human
Specificity: Human CD16/FCGR3
Analysis mode: FCM
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Alternate names: Fc receptor, IgG, low affinity III
Form: Liquid
Shipping: This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage: This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.
Purification method: Protein A
Conjugation: Unconjugated
Immunogen: Recombinant Human CD16b/Fc gamma RIIIb Protein
Buffer: 0.2 μm filtered solution in PBS
Application: Fc Receptors

Fc receptors bind the most common class of antibody, IgG, are called Fc gamma receptors (FcγR). FcγR is divided into three classes, Fc γ RI (CD64), Fc γ RII (CD32), and Fc γ RIII (CD16). CD16 protein is a multifunctional, low/intermediate affinity receptor, which belongs to the immunoglobulin superfamily. It is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. Mouse CD16 is encoded by a single gene, while, human CD16 is expressed as two distinct forms (CD16a/FcγRIIIa and CD16b/FcγRIIIb) encoded by two different highly homologous genes in a cell type-specific manner. CD16 is involved in phagocytosis, secretion of enzymes, inflammatory mediators, antibody-dependent cellular cytotoxicity (ADCC), and clearance of immune complexes.

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