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Anti-c-Kit Antibody (APC)

  • Product Information
  • Description
Catalog: C-FC-3199A
Product Type: FCM Antibody
Size: 25 Tests/100 Tests
Concentration: 5 μl/Test, 0.1 mg/ml
Reactivity: Human
Specificity: Human c-Kit
Analysis mode: FCM
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1
Alternate names: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Form: Liquid
Shipping: This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage: This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze !
Purification method: Protein A
Conjugation: APC
Immunogen: Recombinant Human c-Kit Protein
Buffer: Aqueous solution containing 0.5% BSA and 0.03%ProClin300
Application: Cancer Drug Targets; Cardiac Stem Cell Markers; Receptor Tyrosine Kinases (RTKs)

C-Kit is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to the protein kinase superfamily, tyr protein kinase family, and CSF-1/PDGF receptor subfamily. C-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. C-Kit has tyrosine-protein kinase activity. Binding of the ligands leads to the autophosphorylation of KIT and its association with substrates such as phosphatidylinositol 3-kinase. Antibodies to c-Kit are widely used in immunohistochemistry to help distinguish particular types of tumor in histological tissue sections. It is used primarily in the diagnosis of GISTs. In GISTs, c-Kit staining is typically cytoplasmic, with stronger accentuation along the cell membranes. C-Kit antibodies can also be used in the diagnosis of mast cell tumors and in distinguishing seminomas from embryonal carcinomas. Mutations in the c-Kit gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Defects in KIT are a cause of acute myelogenous leukemia (AML). AML is a malignant disease in which hematopoietic precursors are arrested in an early stage of development. Note=Somatic mutations that lead to constitutive activation of KIT are detected in AML patients.

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